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抗生素的使用和非酒精性脂肪肝疾病的发展:基于人口的病例控制研究

Fahim Ebrahimi^1,2, Tracey G Simon^3,4,5, Hannes Hagström^6,7

¹Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Liver international : official journal of the International Association for the Study of the Liver

|June 30, 2023

概括

抗生素使用与患非酒精性脂肪性肝病 (NAFLD) 的风险更高,特别是在没有代谢综合征的人群中. 诺基诺显示了最高的关联,在兄弟姐妹的比较中发现一致.

科学领域:

胃肠病学胃肠病学
肝病学肝病学是一种肝病学.
微生物学微生物学

背景情况:

抗生素可以破坏肠道微生物群,可能导致非酒精性脂肪肝疾病 (NAFLD).
以前的研究表明肠道失调和NAFLD之间存在联系,但使用肝脏组织学数据的大规模研究是有限的.

研究的目的:

调查抗生素使用与发展组织学证实NAFLD的风险之间的关联.
探索这种关联是否根据NAFLD的严重程度或代谢综合征的存在而有所不同.

主要方法:

在瑞典进行的一项全国性病例控制研究,涉及成年人与组织学确认的早期NAFLD和匹配的人口对照.
在匹配日期前一年收集了累积抗生素分发的数据.
使用条件后勤回归和兄弟对比分析来计算调整的赔率比率 (aOR).

主要成果:

抗生素使用与剂量依赖的NAFLD的几率增加1.35倍有关.
这种关联在NAFLD的所有组织学阶段都是一致的,并且在兄弟姐妹的比较中强大.
诺基诺显示出最高的风险 (aOR 1.38).
抗生素使用仅在没有代谢综合征的患者中与NAFLD有关 (aOR1.63),而不是在有代谢综合征的患者中 (aOR1.09).

结论:

暴露于抗生素可能是发生NAFLD的危险因素,特别是在没有代谢综合征的个体中.
调查结果强调诺基诺与最高风险有关.
兄弟姐妹比较中的强有力的关联表明,独立于共同的遗传和早期环境因素的重要联系.

关键词:

抗生素抗生素是一种抗生素.这种疾病叫做dysbiosis.肠 - 肝轴肠 - 肝轴代谢综合征代谢综合征微生物组是一个微生物组.非酒精性脂肪性肝病是什么?

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