来自海洋来源的生物活性化合物:一种潜在的免疫疗法治疗方法
Yaruq Jabeen1, Numan Yousaf1, Mohd Sani Sarjadi2
1Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
Journal of biomolecular structure & dynamics
|June 30, 2023
概括
海洋藻产生了编程细胞死亡受体连接体-1 (PD-L1) 的潜在抑制剂,这是癌症免疫疗法的标. 富可丁醇表现出强烈的结合,表明其作为新型治疗剂的潜力.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 免疫治疗是一种免疫疗法.
- 计算机化药物发现.
背景情况:
- 免疫疗法利用检查点抑制剂阻止诸如编程细胞死亡受体-1 (PD-1) 和编程细胞死亡受体连接体-1 (PD-L1) 等相互作用,这对于调节免疫反应至关重要.
- 海洋环境是一个丰富的,但尚未探索的,新型小分子的来源,具有治疗潜力.
研究的目的:
- 研究藻类衍生小分子作为PD-L1.1抑制剂的潜力.
- 使用计算方法识别具有与PD-L1高结合亲和度的特定化合物.
主要方法:
- 使用分子对接对PD-L1进行19种藻类衍生小分子的选.
- 吸收,分布,新陈代谢和分泌 (ADME) 属性的评估.
- 分子动力学模拟 (MDS) 用于评估复杂的稳定性.
主要成果:
- 六种化合物表现出显著的结合能,范围从-11.1到-9.1kcal/mol.
- 富可丁醇表现出最强的结合亲和力 (-11.1 kcal/mol) 与关键的 PD-L1.1 的键.
- MDS证实了已识别的配体与PD-L1蛋白之间的稳定相互作用.
结论:
- 藻类衍生化合物,特别是富可森丁醇,显示出作为新型PD-L1抑制剂的前景.
- 这些发现支持开发用于癌症免疫治疗的海洋天然产品.
更多相关视频
10:02Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
Published on: June 2, 2023
2.0K
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
相关概念视频
Microorganisms in Medicine and Therapeutics
64
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
64
Tumor Immunotherapy
573
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
573
Cancer Vaccines
428
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
428
Antigens Involved in Adaptive Immunity
560
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
560
