在患有主要胃肠道癌症的患者中,与年龄特定的心血管疾病相关的死亡率:基于SEER人口的SEER研究
1Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, China.
Cancer medicine
|June 30, 2023
概括
年龄显著增加了患有主要胃肠道癌症的患者心血管疾病 (CVD) 死亡的风险. 与年轻患者相比,老年人面临的与心血管疾病相关的死亡率要高得多.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 年龄是心血管疾病 (CVD) 死亡率的已知风险因素.
- 关于主要胃肠道癌症中年龄和心血管疾病死亡率之间的具体关系的研究有限.
- 了解这种联系对于患者管理和风险分层至关重要.
研究的目的:
- 在被诊断患有主要胃肠道癌症的患者中调查年龄和心血管疾病 (CVD) 相关死亡率之间的关联.
- 量化这些癌症群体中不同年龄组的心血管疾病死亡风险.
- 确定诊断时的年龄和心血管疾病死亡率之间的潜在非线性关系.
主要方法:
- 使用来自监测,流行病学和最终结果 (SEER) 注册表 (2000-2015) 数据的回顾性队列研究.
- 包括患有结直肠,胰腺,肝细胞,胃和食道癌症的患者.
- 统计分析包括标准化死亡率 (SMR),竞争风险回归和限制立方线 (RCS) 模型.
主要成果:
- 对576,713名患有主要胃肠道癌症的患者的分析.
- 患有胃肠道癌症的患者,与心血管疾病相关的死亡率高于美国普通人口.
- 在所有研究的癌症类型中,在中年和老年患者中观察到对心血管疾病死亡率显著增加的调整后次危险比率,老年患者的风险明显更高.
结论:
- 年龄被证实是患有主要胃肠道癌症的患者心血管疾病 (CVD) 相关死亡率的重要风险因素.
- 该研究强调了诊断时的年龄与结直肠,胰腺和食道癌的心血管疾病死亡率之间的非线性关系.
- 这些发现强调了在胃肠道癌症患者的瘤护理中考虑与年龄有关的心血管风险的重要性.
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