[昼夜节律的和振荡从阴影中出来]
Michèle Teboul1, Franck Delaunay1
1Université Côte d'Azur, CNRS, Inserm, institut de biologie Valrose (iBV), Nice, France.
概括
研究人员发现了独立于主要的昼夜节律的12小时生物钟,影响了像新陈代谢这样的基本细胞功能. 这种涉及XBP1的超射频振荡器是古老的,可能反映了地球较短的早期.
科学领域:
- 分子生物学分子生物学
- 时间生物学 时间生物学
- 遗传学 遗传学 是一个
背景情况:
- 大约40%的肝脏转录表现出昼夜表达模式.
- 最近已经确定了独立于主要昼夜时钟的波振荡.
- 12小时周期的转录调节了基本的细胞过程,包括蛋白质稳定,脂质和RNA代谢.
研究的目的:
- 调查超射线振荡器的存在和性质.
- 为了识别12小时超射频振荡器的关键分子组件.
- 为了探索这种振荡的进化起源.
主要方法:
- 对肝脏转录组表达模式的分析.
- 振荡转录及其调节网络的识别.
- 进化保护的生物信息分析.
主要成果:
- 发现了一个保存的12小时超频振荡器,涉及未折叠蛋白质响应 (UPR) 调节器X盒结合蛋白1 (XBP1),联合激活器SRC-3和斑点蛋白SON.
- 这个振荡器与12小时的超日光转录组相连.
- 高度的保护表明其起源很古,可能早于当前的24小时一天.
结论:
- 一个由XBP1协调的12小时超频振荡器存在,它独立于规范的昼夜钟运行.
- 这种振荡器调节细胞核心功能,并且在各种物种中高度保存.
- 它的古老性质表明,它可能是行星日较短的时期的遗迹.
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