从出生到青春期前,C-反应蛋白的进展因传递方式而异
Alexandra R Sitarik1, Christine C Johnson1, Albert M Levin1
1Department of Public Health Sciences, Henry Ford Health, Detroit, MI, United States.
Frontiers in pediatrics
|June 30, 2023
概括
计划式剖腹产与儿童炎症和BMI的增加有关,与紧急剖腹产不同. 经历分娩可以通过降低全身炎症来降低长期慢性疾病的风险.
科学领域:
- 儿科慢性疾病 儿童慢性疾病
- 炎症标志物的炎症标志物
- 出生后的结果.
背景情况:
- 剖腹产 (剖腹产) 与儿童慢性疾病风险增加有关,可能是由于全身炎症.
- 特定的剖腹产类型可能有不同的影响,紧急剖腹产通常涉及分娩或膜破裂.
研究的目的:
- 调查从出生到青春期前的传递方式和纵向高灵敏性C反应蛋白 (hs-CRP) 档案之间的关联.
- 确定hs-CRP是否调解了分娩方式和青春期前的身体质量指数 (BMI) 之间的关系.
主要方法:
- 从WHEALS出生队列 (N=564) 的数据分析.
- 长度血hs-CRP水平测量从出生到10岁.
- 用于识别hs-CRP轨迹的增长混合模型 (GMMs);风险比率的Poisson回归.
主要成果:
- 确定了两个hs-CRP轨迹:低 (76%) 和高/增加 (24%).
- 与阴道分娩相比,计划的剖腹产增加了高hs-CRP轨迹的风险 (RR=1.15,p=0.028).
- 没有发现无计划剖腹产的相关性;hs-CRP类介导了计划剖腹产对10岁BMIz-score影响的43.4%.
结论:
- 经历分娩可能会导致较低的童年系统性炎症和降低青春期前的BMI.
- 研究结果表明,劳动对减轻长期慢性疾病发展有潜在的益处.
- 产生的方式和劳动经验可能会影响炎症途径,影响儿童的健康结果.
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