子宫炎症状态通过产母的酸运输和母体蛋白质合成调节卵矿化
Jia Feng1,2, Mingyuan Lu1, Lingling Ma1
1Laboratory of Quality & Safety Risk Assessment for Animal Products on Feed Hazards (Beijing) of the Ministry of Agriculture & Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing, 100081, China.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
|June 30, 2023
概括
产母的子宫炎症通过影响矿化和结构,损害了蛋的质量. 食精油 (EO) 可以缓解炎症,改善蛋的厚度和强度.
科学领域:
- 动物科学动物科学
- 生殖生物学 生殖生物学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 子宫炎症可能会对产母的生殖功能产生负面影响.
- 蛋质量对于家禽生产至关重要,并受到各种生理因素的影响.
研究的目的:
- 研究由脂聚糖 (LPS) 诱导的子宫炎症对蛋矿化,超结构和机械性能的影响.
- 评估饮食必需油 (EO) 补充剂在减轻LPS诱导的子宫炎症和改善蛋质量的有效性.
主要方法:
- 产母被挑战用LPS诱导子宫炎症 (试验1).
- 食精油 (EO) 在不同度 (0-200 mg/kg) 中补充,以评估其保护作用 (试验2).
- 评估卵参数,包括厚度,机械性能和超结构,以及与炎症和运输相关的子宫基因表达.
主要成果:
- 由LPS引起的子宫炎症显著降低了蛋厚度,机械强度和改变的超结构.
- 炎症导致子宫基因蛋白 (OVOTRANSFERRIN,OVALBUMIN) 和结合蛋白 (CALBINDIN-1) 的表达发生改变.
- EO补充剂缓解了炎症,改善了蛋的厚度和强度,并积极调节了基因表达,在100 mg/kg时具有最佳效果.
结论:
- 子宫炎症通过破坏运输和矩阵蛋白质合成,对卵质量产生负面影响.
- 食精油显示出改善子宫炎症和提高产母蛋质量的潜力.
- 这项研究提供了对由炎症介导的卵修饰背后的机制的新见解.
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