神经调节在新出现的耐火状态发症患者中
Ioannis Stavropoulos1,2, Jin Han Khaw3, Antonio Valentin1,2
1Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
像ECT,VNS和DBS这样的神经调节技术在治疗急性新发性耐火状态 (NORSE) 和发烧性感染相关综合征 (FIRES) 中显示出前景,在20名患者中,有17名患者实现了解决.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 关键护理医学 关键护理医学
背景情况:
- 新发 refractory status epilepticus (NORSE) 和发烧性感染相关综合征 (FIRES) 是严重的神经紧急情况,死亡率和发病率高.
- 目前的治疗方法,包括麻醉剂和免疫疗法,往往产生低于最佳的结果.
- 迫切需要有效的干预措施来管理NORSE/FIRES的急性阶段.
研究的目的:
- 系统地审查神经调节技术在NORSE/FIRES急性阶段的应用和有效性.
- 评估早期神经调节在管理这些破坏性疾病中的潜在临床益处.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 在文献搜索中,发现了15篇相关文章,详细介绍了NORSE/FIRES对20名神经调节患者的治疗.
主要成果:
- 神经调节技术包括电疗法 (ECT),神经刺激 (VNS) 和深度大脑刺激 (DBS).
- 在20名患者中,有17名 (85%) 在神经调节后经历了状态的消失.
- 在研究期间,有3名患者 (15%) 死亡.
结论:
- 神经调节技术在NORSE/FIRES的急性管理中显示出潜在的临床益处.
- 早期考虑神经调节可能会改善这些破坏性条件下的结果.
- 由于样本规模有限和治疗方案的异质性,需要进行进一步的研究.
更多相关视频
09:06Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
05:54Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
Published on: June 13, 2016
相关概念视频
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Antiepileptic Drugs: Glutamate Antagonists
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
