对于患有阻塞性睡眠呼吸暂停的急性缺血性中风患者90天功能结果的性别差异
Adriana N Devenish1, Tariq Nisar2, Amber Criswell3
1Neurological Institute, Houston Methodist Hospital, Houston, USA.
Cureus
|June 30, 2023
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的男性在急性缺血性中风 (AIS) 后面临着功能不良结果的两倍风险. 早期的OSA诊断和治疗对于男性中风幸存者来说至关重要,以改善恢复.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与急性缺血性中风 (AIS) 有关,并恶化了患者的结果.
- OSA可能会导致内皮和脑组织损伤,影响中风恢复.
- 对OSA对AIS结果的影响的性别差异需要调查.
研究的目的:
- 评估OSA和AIS患者90天功能结果的基于性别的差异.
- 评估修改后的兰金级别 (mRS) 评分作为功能结果的衡量标准.
主要方法:
- 来自休斯顿卫理医院HOPES注册表 (2016-2022) 的OSA和AIS患者的回顾性研究.
- 纳入标准:在AIS之前或在90天内诊断OSA.
- 多变量后勤回归调整为人口统计,NIHSS和并发症.
主要成果:
- 这项研究包括291名女性和449名患有OSA和AIS的男性.
- 男人表现出更高的并发病率,如心房动和内出血.
- 男性有显著更高的风险 (OR=2.35) 90天的功能结果差 (p < 0.001).
结论:
- 在OSA患者中,男性性别与AIS后90天功能不良结果的风险增加了一倍.
- 潜在的促成因素包括更严重的氧气脱,氧化应激和男性的呼吸道阻塞.
- 建议加强OSA的早期诊断和治疗,以减轻男性中风幸存者的不良结果.
相关概念视频
01:21Sleep Apnea
195
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
195
01:24Substance Use Disorders Affecting Sleep
198
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
198