对C反应性蛋白与明显的超炎性生物标志物的比较,与COVID-19严重程度,死亡率和SARS-CoV-2变种相关
Tudorita Gabriela Paranga1,2, Mariana Pavel-Tanasa3,4, Daniela Constantinescu3,4
1Department of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.
C-反应蛋白 (CRP) 最好预测COVID-19的严重程度. 其他生物标志物,如乳酸脱酶 (LDH),可溶性触发受体表达在骨髓细胞-1 (sTREM-1),肝细胞生长因子 (HGF) 有效预测COVID-19患者的死亡率.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 (由SARS-CoV-2引起) 与高炎症和细胞因子风暴有关,导致严重的结果.
- 确定可靠的生物标志物来预测COVID-19的严重程度和死亡率至关重要.
研究的目的:
- 为了比较C-反应蛋白 (CRP) 与其他炎症生物标志物的预测效率,用于COVID-19的结果.
- 评估新型调节剂 (suPAR,sTREM-1,HGF) 和经典标记物 (MCP-1,IL-1β,IL-6,NLR,PLR,ESR,费里丁,纤维素,LDH) 在预测疾病严重程度和死亡率方面.
主要方法:
- 在COVID-19患者入院后测量了CRP和各种生物标志物的血清水平.
- 该研究比较了这些生物标志物的能力,以区分严重和不严重的疾病和预测死亡率.
主要成果:
- 患有严重COVID-19的患者表现出较高的CRP,suPAR,sTREM-1,HGF和其他经典生物标志物的水平.
- CRP是区分严重和非严重COVID-19病例的最有效生物标志物.
- 确定LDH,sTREM-1和HGF是死亡率的强有力的预测因素.
- 溶性泌尿酸酶等离子体激活体受体 (suPAR) 在鉴定三角洲变种感染的特征方面尤其重要.
结论:
- CRP是评估COVID-19严重程度的一个关键生物标志物.
- LDH,sTREM-1和HGF是COVID-19患者死亡率的有价值预测因素.
- suPAR在了解Delta变种感染方面发挥着重要作用.
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