肠病原性大肠杆菌诱导的腹的病理生理学
Prabhdeep Kaur1, Pradeep K Dudeja2
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Illinois, United States of America.
概括
非典型的肠病原性大肠杆菌 (aEPEC) 在全球范围内越来越普遍. 本综述详细介绍了EPEC分类,流行病学和毒性,强调了对婴儿腹进行更好的诊断的必要性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 肠病原性大肠杆菌 (EPEC) 是幼儿的重要腹病原体.
- 不典型的EPEC (aEPEC) 现在在全球范围内比典型的EPEC (tEPEC) 更常见.
- 由于其发病率不断上升,了解EPEC的致病性至关重要.
研究的目的:
- 审查EPEC感染的分类,流行病学和病原性.
- 探索EPEC诱导的腹的毒性决定因素和病理生理学.
- 强调需要改善EPEC在特有地区的诊断方法.
主要方法:
- 在PubMed,EMBASE和Scopus数据库中进行全面的文献搜索.
- 包括来自作者自身研究的同行评审证据.
- 对EPEC毒性机制的现有知识的审查,包括A/E病变和T3SS.
主要成果:
- 流行病学数据显示,与tEPEC相比,aEPEC感染的总体增加.
- 附着和消除 (A/E) 病变的机制和三类分泌系统 (T3SS) 是关键的毒性因素.
- EPEC诱导的腹的病理生理机制需要进一步阐明.
结论:
- aEPEC代表着日益严重的全球健康问题,特别是在儿童群体中.
- 对EPEC毒性和腹机制的进一步研究是有必要的.
- 开发快速,经济高效的EPEC诊断对于临床管理至关重要.
相关概念视频
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
162
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
162
Inflammatory Bowel Disease I: Ulcerative Colitis
223
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
223
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
252
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
252
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
248
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
248
Inflammatory Bowel Disease II: Crohn's Disease
299
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
299
Chronic Bowel Disorders: Introduction
489
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
489


