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COVID-19 (PASC) 后急性继发症的病理生理学:可能对持续性炎症起作用
1Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA.
Asia Pacific allergy
|June 30, 2023
概括
持续性炎症在长期COVID (COVID-19的后急性后续症) 中起着关键作用. 了解这些炎症途径对于开发长期COVID患者的有效治疗方法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 病理生理学 病理生理学
背景情况:
- 后急性COVID-19 (PASC) 或长期COVID的后续影响许多患者在最初的SARS-CoV-2感染后.
- 长期COVID的病理生理学尚不清楚,但持续的炎症被怀疑是主要的促成因素.
研究的目的:
- 审查有关炎症在PASC病理生理学中的作用的现有数据.
- 探索了解炎症如何影响PASC的诊断和治疗.
主要方法:
- 包括PubMed,MeSH,NLM目录和clinicaltrials.gov.gov在内的公共数据库的全面审查.
主要成果:
- 文献支持PASC中各种炎症反应的重要作用.
- 在PASC的炎症可以表现为持续的SARS-CoV-2特异性反应,新的自身免疫反应或免疫调节的丧失.
- 这些炎症过程有助于构成症状 (疲劳,认知功能障碍) 和器官特异性功能障碍.
结论:
- PASC是一种独特的临床实体,与其他后病毒综合征有相似之处.
- 目前正在进行的研究旨在确定个体患者的特定炎症途径,以指导COVID-19和未来病毒性疾病的治疗和预防.
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