肺纤维化:严重的COVID-19的短期或长期后果?
Zhen Zheng1, Fei Peng1,2, Yong Zhou1
1Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
概括
严重的COVID-19可以导致肺纤维化,这是一个长期的并发症. 对于幸存者,特别是老年人来说,了解其进展和开发抗纤维菌疗法至关重要.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行严重影响全球医疗保健.
- SARS-CoV-2主要影响呼吸系统,严重病例进展为ARDS.
- 肺纤维化是严重的COVID-19后的ARDS已知的并发症之一.
研究的目的:
- 审查COVID-19在呼吸系统中的病原性.
- 要突出严重的COVID-19中ARDS相关的肺纤维化及其机制.
- 讨论COVID-19幸存者的长期纤维化并发症,特别是老年人.
主要方法:
- 文献综述侧重于COVID-19的病原和肺纤维化.
- 分析了与ARDS相关的肺纤维化背后的机制.
- 讨论潜在的长期后果和治疗策略.
主要成果:
- 严重的COVID-19可能导致急性呼吸系统应急综合征 (ARDS).
- 与ARDS相关的肺纤维化是COVID-19的一种已知的后果.
- 目前尚不清楚COVID-19后肺纤维化的长期病程 (可溶解,持久或渐进) 是什么.
结论:
- 了解COVID-19的长期后果,如肺纤维化,至关重要.
- 确定患有慢性肺纤维化风险的COVID-19幸存者是一个优先事项.
- 开发有效的抗纤维化疗法对于管理COVID-19后肺部并发症至关重要.
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