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YAP1作为EGFR突变非小细胞肺癌免疫检查点抑制剂的新型负生物标志物

Ling-Chen Li¹, Xie-Wan Chen^1,2, Ling Fang¹

¹Cancer Institute, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.

Canadian respiratory journal

|June 30, 2023

概括

是1-关联的转录调节器 (YAP1) 预测表皮生长因子受体 (EGFR) 突变非小细胞肺癌 (NSCLC) 治疗免疫检查点抑制剂 (ICI) 的不良结果. YAP1表明免疫抑制性瘤微环境,将其确定为ICI治疗在这个患者群体中的负面生物标志物.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

免疫检查点抑制剂 (ICI) 是非小细胞肺癌 (NSCLC) 的标准.
药物耐药性限制了EGFR突变NSCLC中的ICI疗效.
在EGFR突变NSCLC的ICI治疗中YAP1的作用需要澄清.

研究的目的:

研究YAP1在EGFR突变NSCLC的ICI治疗反应中的作用.
确定YAP1作为EGFR突变NSCLC中ICI治疗的潜在生物标志物.

主要方法:

使用TCGA和GEO数据集用于NSCLC患者数据.
根据YAP1的表达,患者分为YAP1_高和YAP1_低的分层组.
使用cBioPortal和TIMER分析了基因改变,免疫细胞透和与瘤相关的抗原.
对临床试验数据 (NCT03513666) 进行了生存分析,以评估YAP1的预测价值.

主要成果:

在EGFR突变NSCLC中,YAP1表达是预后不良的因素.
EGFR基因积极调节YAP1的表达.
YAP1-高的瘤表现出一种免疫抑制的"冷"免疫微环境.
YAP1-低瘤表现出一种免疫活性",热"的表型.
在ICI治疗后,YAP1-高患者的无进展和整体存活时间显著缩短.

结论:

YAP1调解一种免疫抑制的微环境,并预测EGFR突变NSCLC的预后不佳.
在EGFR突变NSCLC中,YAP1作为ICI治疗疗效的新型负生物标志物.

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