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在阻塞性睡眠呼吸暂停综合征中,平均血小板体积和心血管疾病之间的关联

Souha Kallel¹, Khouloud Kchaou¹, Ines Kharrat¹

¹Department of ENT and Cervicofacial Surgery. Habib Bourguiba's Teaching Hospital, University of Sfax, Sfax, Tunisia.

SAGE open medicine

|June 30, 2023

概括

平均血小板体积 (MPV) 与阻塞性睡眠呼吸暂停综合征 (OSAS) 中的心血管疾病有关. 在OSAS患者中,较高的MPV水平与心血管风险增加有关.

科学领域:

心脏病学心脏病学
睡眠医学睡眠医学
血液学血液学血液学

背景情况:

阻塞性睡眠呼吸暂停综合征 (OSAS) 与心血管疾病 (CVD) 有关.
平均血小板体积 (MPV) 是前血栓状况和心血管风险的标志物.
在OSAS患者中,MPV和心血管疾病之间的关系需要进一步调查.

研究的目的:

研究阻塞性睡眠呼吸暂停综合征 (OSAS) 患者的平均血小板体积 (MPV) 和心血管疾病 (CVD) 之间的关联.

主要方法:

对207名被诊断患有OSAS的患者通过测谎术进行了回顾性分析.
根据呼吸暂停-呼吸暂停指数 (AHI) 将患者分为简单的打,轻度,中度和严重的OSAS组.
记录了MPV水平和心血管疾病的存在 (高血压,心力衰竭,冠状动脉疾病,心律失常);多重逻辑回归用于识别预测因素.

主要成果:

与轻度,中度或简单打组相比,严重的OSAS中MPV显著更高 (p<0.05).
在MPV和AHI之间观察到正相关性 (r=0.424;p<0.001).
在OSAS中,心血管疾病的独立预测因素是年龄,体重指数和MPV (OR=2.092;p<0.001).

结论:

平均血小板体积与患有阻塞性睡眠呼吸暂停综合征的患者的心血管疾病有关.
升高的MPV可以作为OSAS患者心血管疾病风险的预测指标.
进一步研究MPV在OSAS病理生理学和心血管结果中的作用是有必要的.

关键词:

心血管疾病的心血管疾病.血小板的平均体积是多少阻塞性睡眠呼吸暂停综合征

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