使用定量点照顾测试对葡萄糖-6-酸盐脱酶缺乏症的人口查:系统性审查
Mohamed Afiq Hidayat Zailani1, Raja Zahratul Azma Raja Sabudin1, Azlin Ithnin1
1Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.
Frontiers in genetics
|June 30, 2023
概括
对于预防疟疾治疗中的血液溶解性贫血来说,对葡萄糖-6-酸盐脱酶 (G6PD) 缺陷查的定量点治疗测试至关重要. "CareStartTM"和"标准G6PD"套件显示出高精度和可靠性,可有效地对人口进行查.
科学领域:
- 临床诊断 临床诊断 临床诊断
- 寄生虫学的寄生虫学
- 公共卫生 公共卫生
背景情况:
- 葡萄糖-6-酸盐脱酶 (G6PD) 缺乏症是疟疾流行地区普遍存在的X相关疾病,在使用抗疟疾药物 (如普里马奎因) 时可能导致血清性贫血的风险.
- 目前的G6PD查方法复杂,可能会错误分类个体,特别是具有中间G6PD活性的女性.
- 定量点照顾 (POC) 测试为改善人口查和预防药物诱导的血溶性疾病提供了一个有希望的解决方案.
研究的目的:
- 评估G6PD缺陷查的定量点照顾 (POC) 测试的类型和诊断性能.
- 评估这些POC测试在促进消除疟疾感染的有效性.
主要方法:
- 在Scopus和ScienceDirect上对2016年11月以后发表的英语研究进行了系统的文献搜索.
- 关键词包括"葡萄糖酸脱酶"或"G6PD","护理点","查"或"流行","生物传感器"和"定量".
- 该审查遵循PRISMA指南,分析了来自7项纳入研究的数据.
主要成果:
- 评估了两个定量POC测试,即CareStartTM生物传感器和标准G6PD套件.
- 这两种测试都显示出高性能,灵敏度在72%至100%之间,特异性在92%至100%之间.
- 准确度在86%至98%之间,正预测值 (PPV) 从35%到72%,负预测值 (NPV) 从89%到100%.
结论:
- 在高G6PD流行率的疟疾流行地区,对G6PD缺乏量的量化POC测试至关重要.
- CareStartTM生物传感器和STANDARD G6PD套件具有很高的可靠性,性能与光谱法相提并论.
- 这些经过验证的POC测试可以显著改善G6PD查和疟疾治疗安全性.
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