在长期COVID中,免疫功能障碍和巨细胞激活综合征
Stevent Sumantri1, Iris Rengganis2
1Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Banten, Indonesia.
Asia Pacific allergy
|June 30, 2023
概括
长期COVID-19影响全球数百万人,导致免疫失调和器官功能障碍. 研究表明与巨细胞激活综合征 (MCAS) 有关,为治疗提供了新的途径.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 后病毒综合征 后病毒综合征
背景情况:
- 长期COVID-19影响全球超过6500万人,主要影响36-50岁年龄组.
- 患者经历了多器官功能障碍,长期的后果和生活质量的降低.
- 与其他后病毒综合征重叠的危险因素表明了更广泛的研究益处.
研究的目的:
- 探索长期COVID-19的免疫基础.
- 调查巨细胞激活在长期COVID-19病理生理学中的作用.
- 评估向巨细胞激活对患者康复的潜力.
主要方法:
- 长期COVID-19中免疫系统调节失调的审查.
- 对巨细胞激活标记物和细胞因子概况的分析.
- 长期COVID-19临床表现与巨细胞激活综合征 (MCAS) 的比较.
主要成果:
- 长期COVID-19涉及免疫调节失调,包括T细胞变化,先天性免疫过活,以及高水平的促炎细胞因子.
- 持续的SARS-CoV-2储存和感染后的后果有助于这种情况.
- 观察到具有异常颗粒和过度细胞因子释放的激活性巨细胞.
结论:
- 长期COVID-19与巨细胞激活综合征 (MCAS) 有临床相似之处.
- 在长期COVID-19患者中诊断和治疗MCAS可能会减轻症状.
- 管理巨细胞介导的超炎症可以帮助长期COVID-19患者的长期康复.
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