酸感应离子通道在心血管功能中的作用
Omar López-Ramírez1, Antonia González-Garrido2
1Instituto de Oftalmología Fundación de Asistencia Privada Conde de Valenciana, I.A.P., Mexico City, Mexico.
Frontiers in physiology
|June 30, 2023
概括
酸感应离子通道 (ASIC) 是神经元中发现的质子传感器. 本综述探讨了它们在心脏功能和心血管调节中的新兴作用,包括疼痛和运动反应.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 酸感应离子通道 (ASIC) 是对神经元刺激性,突触可塑性和感官功能至关重要的质子传感器.
- 虽然ASIC在神经元中得到了很好的研究,但它们在心肌细胞功能中的作用在很大程度上仍未被探索.
- ASIC子单元存在于哺乳动物心肌细胞的等离子膜和细胞内部分,表明了新的生理功能.
研究的目的:
- 审查目前对ASIC通道表达和功能在心血管系统及其内化系统的理解.
- 要突出ASICs在机械感觉,化学感觉,心脏疼痛,缺血损伤和运动压力反射中的参与.
主要方法:
- 本综述总结了各种研究报告和研究的发现.
- 对ASIC通道表达和功能在心血管组织和相关神经元中的现有文献的分析.
- 整合了关于ASIC在巴罗受体和背根结质神经元中发挥作用的数据,这些神经元能刺激心脏.
主要成果:
- ASIC通道表达在神经元内心脏中,充当机械传感器和化学传感器.
- 结节腺神经元中的ASIC2a通道参与检测动脉压力变化.
- ASIC2a/3通道参与感知心脏缺血性疼痛,ASIC1a参与缺血引起的损伤,ASIC1a,2和3参与运动压力反射.
结论:
- ASIC通道在心血管生理学和病理生理学中发挥着多样化和重要的作用.
- 对心肌细胞中ASIC的进一步研究可能会揭示心血管疾病的新治疗点.
- ASIC是调节心血管功能的感觉通路的关键组成部分,包括疼痛和运动反应.
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