一个双向的门德尔随机化研究关于早晨血皮质醇在注意力缺陷多动症障碍中的作用
Hu Jue1, Li Fang-Fang1, Chen Dan-Fei1
1First Clinical School, Zhejiang Chinese Medical University, Hangzhou, China.
Frontiers in psychiatry
|June 30, 2023
概括
较低的早晨血皮质醇水平与注意力缺陷多动障碍 (ADHD) 有关,这表明存在反向因果关系. ADHD可能会显著降低早晨的血皮质醇分泌,但皮质醇不会因果关系地影响ADHD风险.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 皮质醇由下丘脑-垂体-上腺 (HPA) 轴调节,已与注意力缺陷多动性障碍 (ADHD) 相关.
- 这种关系的确切性质,包括因果关系和潜在的反因果关系,仍在争论中.
- 了解这种联系对于ADHD研究和潜在的治疗策略至关重要.
研究的目的:
- 为了研究早晨血皮质醇水平和ADHD之间的双向因果关系.
- 区分皮质醇对ADHD的直接因果作用和ADHD对皮质醇水平的逆因果作用.
主要方法:
- 使用双向的双样本孟德尔随机化 (MR) 设计.
- 使用来自大型联盟 (精神病基因组学协作和CORtisol网络) 的遗传数据.
- 应用各种MR分析 (IVW,MR-Egger,加权中位数) 和灵敏度分析 (leave-one-out,MR-PRESSO) 来确保结果的可靠性.
主要成果:
- 发现了反向因果关系:较低的早晨血皮质醇水平与ADHD有关 (OR = 0.857,P = 0.018).
- 没有发现早晨血皮质醇水平对ADHD风险的显著因果关系 (OR = 1.006,P = 0.907).
- 灵敏度分析证实了研究结果的稳定性和可靠性,没有证据表明性或弱仪器变量.
结论:
- 这项研究表明,ADHD与较低的早晨血皮质醇水平有关,这表明有反向的因果关系.
- 没有遗传证据支持早晨血皮质醇对患ADHD风险的因果关系.
- 这些发现表明,ADHD可能会影响皮质醇的分泌,而不是皮质醇直接导致ADHD.
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