亚托匹性皮肤炎衍生的金黄色葡萄球菌菌株:什么使它们在与宿主相互作用中变得特别?
Antonietta Lucia Conte1, Francesca Brunetti1, Massimiliano Marazzato1
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Frontiers in cellular and infection microbiology
|June 30, 2023
概括
特定的金黄色葡萄球菌克隆并不是唯一与亚托皮性皮肤炎 (AD) 相关的. 相反,S. aureus的差异性基因表达和翻译后修改可能会影响其在AD病变发生中的作用.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 皮肤病学 皮肤病学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病.
- 黄金葡萄球菌与阿兹海默氏症的发病有关,但其在阿兹海默氏症患者中的遗传多样性尚不清楚.
- 调查与阿尔茨海默氏症相关的特定黄金菌克隆是至关重要的.
研究的目的:
- 调查特定的黄金葡萄球菌克隆是否与阿托皮性皮肤炎有关.
- 分析来自AD患者和健康携带者的S. aureus菌株的遗传多样性和基因组含量.
主要方法:
- 38个S. aureus菌株的全基因组测序 (WGS).
- 基因型鉴定 (MLST,spa,agr,SCCmec) 和对毒性因子和抗生素耐药性基因的分析.
- 现型分析包括抗生素敏感性,生物膜生成和侵入性.
主要成果:
- 来自AD患者的S. aureus菌株显示出高遗传异质性,没有与AD相关的独特基因型或基因组含量.
- 阿尔茨海默病菌株的基因含量变化较低,这表明受炎症条件的选择性压力.
- 与翻译后修饰,蛋白质循环和细胞内运输相关的基因在AD菌株中得到了丰富.
- 所有测试的AD菌株都是强度或中度的生物膜生产者,只有不到一半的AD菌株表现出侵袭性.
结论:
- 在AD皮肤中S. aureus的功能作用可能取决于差异性基因表达和翻译后修改.
- 没有任何特定的遗传特征能够独特地识别与亚托匹性皮肤炎相关的S. aureus菌株.
- 了解阿尔茨海默氏症中黄金菌适应机制是管理这种疾病的关键.
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