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Updated: Jul 25, 2025

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
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Published on: July 7, 2020

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基质衍生型Sortase A抑制剂:向格拉姆阳性病原性细菌的重要毒性因子

Helal Abujubara1, Jordi C J Hintzen1, Shadi Rahimi2

  • 1Department of Chemistry and Molecular Biology, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg Kemigården 4 412 96 Göteborg Sweden alesia.a.tietze@gu.se.

Chemical science
|June 30, 2023
PubMed
概括

研究人员开发了针对细菌Sortase A (SrtA) 的新型皮多米米特抑制剂,这是一个重要的毒性因子. 最强的抑制剂,LPRDSar,显示出强烈的活性,一些化合物抑制了金黄色葡萄球菌的生长和生物膜的形成,提供了潜在的新疗法.

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