患有支气管炎的儿童的肠道微生物群变化
Xiao-Bin Wu1,2, Jian Wang1,2, Yuan Tang1,2
1Chongqing Health Center for Women and Children, Chongqing, China.
Frontiers in microbiology
|June 30, 2023
概括
患有支气管炎的儿童表现出改变的肠道微生物群,有较少的有益细菌和增加的Sphingomonas. 补充Clostridium butyricum可能有助于减少RSV引起的肺炎.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 支气管炎是婴儿常见的呼吸道感染.
- 人们越来越认识到肠道微生物群在儿科疾病中的作用.
研究的目的:
- 调查肠道微生物群变化与儿童支气管炎之间的相关性.
- 为了确定支气管炎发病的潜在微生物生物标志物.
主要方法:
- 对比了57名患有支气管炎的儿童和36名健康儿童的肠道微生物群和代谢物.
- 使用高通量测序,非向的代谢组学和ELISA.
- 在RSV感染的小鼠模型中验证的发现.
主要成果:
- 患有支气管炎的儿童的α多样性明显较低 (Shannon,Simpson,Pielou的均性).
- 观察到短链脂肪酸 (SCFA) 生产细菌 (例如,Firmicutes, Bacteroidetes,Clostridium) 的丰度减少.
- 增加Sphingomonas的丰度和便氨基酸的升高与支气管炎的进展有关.
- 克洛斯特里黄油补充剂在小鼠中缓解了RSV诱导的肺炎.
结论:
- 改变的肠道微生物群,减少的SCFA和升高的螺旋脂质与儿童的支气管炎进展有关.
- 特定的便细菌和代谢物可以预测支气管炎的发病.
- 口服Clostridium butyricum显示出缓解RSV诱导的肺炎的潜力.
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