用于血管异常的普罗巴诺洛尔:儿科患者的疗效和并发症
1Department of Paediatric Surgery, SMS Medical College, Jaipur, Rajasthan, India.
Journal of Indian Association of Pediatric Surgeons
|June 30, 2023
概括
普罗兰诺罗尔化对婴儿血管瘤 (IHs) 和先天性血管瘤 (CHs) 有效. 它显示出作为淋巴和静脉形疾病多模式治疗方法的一部分的潜力.
科学领域:
- 血管外科 血管外科
- 儿科皮肤病学 儿科皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 先天性血管异常被归类为瘤或形.
- 婴儿血瘤 (IH) 是一种常见的血管瘤,在这种瘤中,Propanolol的疗效已经得到证实.
- 这项研究调查了propranolol在各种血管异常中的使用.
研究的目的:
- 为了评估口服普罗普拉诺洛尔和辅助疗法的治疗效果.
- 在儿科血管异常中分析与propranolol治疗相关的并发症.
- 评估propranolol在婴儿血管瘤,先天性血管瘤和血管形中的作用.
主要方法:
- 在第三级护理机构进行为期10年的前性干预研究 (2012-2022年).
- 包括12岁以下患有皮肤血管瘤和淋巴/静脉形的儿童,但不包括有禁忌的儿童.
- 收集有关患者人口统计,病变特征,治疗持续时间,反应和并发症的数据.
主要成果:
- 382名患者 (159名男性,223名女性) 患有481个病变接受了治疗.
- 在81.03%的IH患者,36.36%的CH患者和21.74%的血管形患者中观察到出色的应答率.
- 在6.02%的患者中发生了口服普拉诺洛尔的并发症;是最常见的病变并发症 (5.24%).
结论:
- 甲醇化物已被验证为IH和CHs的第一线治疗.
- 在多式模式策略中,甲醇可以在治疗淋巴和静脉形方面发挥辅助作用.
- 这项研究支持propranolol在相当一部分儿科血管异常中具有实用性,并具有可管理的并发症.
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