长期COVID-19并发症中的血栓栓塞
Leilani A Lopes1, Devendra K Agrawal2
1Western University of Health Sciences, College of Osteopathic Medicine of the Pacific - Northwest, Lebanon.
概括
长期COVID-19会增加中风和血栓栓塞的风险,特别是在高风险患者中. 了解这些风险有助于医疗保健提供者识别和管理COVID-19感染后的潜在血栓事件.
科学领域:
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,急性症状主要影响呼吸系统.
- 长期COVID-19的后果会影响多个器官系统,多达30%的患者感染后3-24周.
- 值得关注的是,与长期COVID-19相关的中风和血栓栓塞的风险增加.
研究的目的:
- 审查将长期COVID-19与中风和血栓栓塞的风险增加联系在一起的拟议病因.
- 要突出患者群体和与长期COVID-19中血栓事件相关的风险因素.
- 帮助医疗保健提供者评估患有这些病理的风险较高的患者.
主要方法:
- 关于长期COVID-19及其与血栓事件的关联的当前文献的审查.
- 分析拟议的病理生理机制,包括高凝血状态和免疫系统失调.
- 确定患者的人口统计和伴随性疾病,使个人易患中风和血栓塞栓症.
主要成果:
- 长期COVID-19与中风和血栓栓塞的风险增加有关.
- 危急病患者,免疫力低下患者,糖尿病患者,高血压患者,呼吸道患者,心血管疾病患者或肥胖患者的风险增加.
- 在患有血栓栓塞的患者中观察到升高的D-二聚体和抗脂抗体,这表明一种高凝血状态.
结论:
- 长期COVID-19可能会诱导一种促炎和高凝血状态,增加中风和血栓栓塞的可能性.
- 慢性免疫系统失调是导致这些血栓形成风险的潜在因素.
- 早期识别和管理风险患者对于预防严重后果至关重要.
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