胎儿大脑中的白质变化与腹腔大
Bianca Horgos1, Miruna Mecea1, Armand Boer1
1Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Frontiers in neuroanatomy
|June 30, 2023
概括
腹腔大脑病变 (VM) 改变胎儿大脑结构,使白质管道变薄和移位. 严重的VM与较高的神经发育延迟和神经障碍相关.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 腹腔大 (VM) 是一个胎儿大脑形.
- 它可以作为一个孤立的条件或与其他异常发生.
- 了解它对大脑结构的影响至关重要.
研究的目的:
- 为了研究心室积血病对胎儿大脑三维内部结构的影响.
- 为了将VM的严重程度与观察到的结构变化和神经发育结果相关联.
主要方法:
- 胎儿超声波诊断出腹腔大,由尸体解剖证实.
- 克林格勒的剖析技术被用来分析大脑结构.
- 大脑被分为中度 (13-15毫米心脏直径) 和严重 (>15毫米) 的VM组.
主要成果:
- 剖析显示,在扩大的心室附近,较薄,较低位移的囊.
- 没有切割的囊的开口扩大了,骨脱离了体.
- 在受影响的大脑中,体凸性被逆转.
结论:
- 腹腔大症显著破坏胎儿大脑白质组织.
- 神经发育迟缓的患病率随着VM严重程度的增加而增加:轻度≥90%正常,中度≥75%,重度≥60%.
- 与VM相关的神经损伤范围从注意力缺陷到精神疾病.
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