癌症患者的丹诺苏马布相关的骨瘤:回顾性描述性病例系列研究研究
Ji-Yeon Kang1, Sang-Yup Kim2,3, Jae-Seok Lim4
1Department of Oral & Maxillofacial Surgery, College of Medicine, Chungnam National University, Moonhwa-ro 282, Jung-Gu, Daejeon, 35015, Korea.
Maxillofacial plastic and reconstructive surgery
|June 30, 2023
概括
关联骨硬化 (DRONJ) 是癌症患者的一个风险. 在大多数情况下,保守性手术,抗生素和停止使用denosumab (DMB) 都有效治疗了DRONJ.
科学领域:
- 在瘤学瘤学.
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 德诺苏马布 (DMB) 是一种治疗骨质疏松症和转移性癌症的骨抗吸收剂.
- 关联的骨髓缩 (DRONJ) 是癌症患者的一个重要并发症.
- 在双酸盐和诺苏马布使用者中,ONJ的患病率类似,在使用抗血管原剂时增加.
研究的目的:
- 在癌症患者中报告与denozumab相关的下骨 necrosis (DRONJ).
- 为了确定DRONJ的风险因素和有效的治疗策略.
主要方法:
- 对四名DRONJ癌症患者的回顾性分析,这些患者接受了denosumab (Xgeva®,120mg) 治疗.
- 确定了包括最近拔牙在内的风险因素.
- 对炎症和感染进行病理学检查.
主要成果:
- 四名患者中有三名 (前列腺癌,乳腺癌) 患有DRONJ.
- 在停止服用登苏马布后两个月内拔牙是危险因素.
- 三名患者通过连续切除术,抗生素和停止使用denosumab成功治疗和愈合.
结论:
- 保守的手术管理与抗生素和denosumab停止相结合,对DRONJ是有效的.
- 需要进一步研究类固醇,抗癌药物的作用以及与denosumab的药物相互作用.
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