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伪二烯对大鼠胎儿骨发育的影响:通过三种不同的方法进行评估

Hüseyin Yiğit¹, Esra Balcıoğlu², İlyas Uçar³

¹Cappadocia Vocational School, Department of Medical Services and Techniques, Cappadocia University, Nevsehir, Turkey. anatomisth@gmail.com.

Anatomical science international

|June 30, 2023

概括

怀孕期间使用伪氨酸 (PSE) 会对胎儿长骨发育产生负面影响. 在怀孕的老鼠中增加PSE剂量导致胎儿生长,骨化和骨含量减少.

科学领域:

药理学药理学是指药理学的学科.
发展生物学发展生物学
毒理学毒理学毒理学

背景情况:

伪 (PSE) 是一种广泛使用的降血剂,存在于许多感冒药中.
孕妇经常使用PSE治疗感冒和咳症状,通常与其他药物结合使用.
由于其常见的使用,怀孕期间暴露于PSE的安全性存在担忧.

研究的目的:

为了研究母体PSE给药对大鼠胎儿骨发育的影响.
为了确定妊娠期间的PSE暴露是否会影响长骨骨化和胎儿生长参数.
评估PSE暴露和不良骨结果之间的剂量依赖关系.

主要方法:

怀孕的老鼠从妊娠的第1天到第20天通过输卵管给予不同剂量的PSE (25-200 mg/kg).
胎儿的参数包括体重和身高在21日剖腹产后被测量.
用三种不同的方法评估股骨和骨骨化,使用SEM-EDX分析骨含量.

主要成果:

孕产妇服用PSE导致胎儿体重,身高和长骨长度的剂量依赖性下降.
随着增加PSE剂量,大腿骨和大腿骨的骨化率显著降低.
在SEM-EDX分析中,暴露于PSE的胎儿的骨组织含量下降.

结论:

孕妇在怀孕期间使用PSE会对小鼠胎儿长骨发育产生不利影响.
对骨生长和骨化观察到的负面影响是剂量依赖的.
在妊娠期间暴露于PSE会破坏骨发育的微妙平衡,突出潜在的风险.

关键词:

在EDX分析中,分析了EDX.形态学形态学形态学骨化过程中的骨化.这就是SEM SEM.甲状腺学甲状腺学是一门学科.

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