与抗生素相关的药物不良反应的可预防性:基于自发报告系统的评估
Ha N Tran1, Tien N T Nguyen1, Ngan T K Tran1
1National Drug Information and Adverse Drug Reaction Monitoring Centre, Hanoi University of Pharmacy, Hanoi, Vietnam.
Therapeutic innovation & regulatory science
|June 30, 2023
概括
与抗生素相关的药物不良反应 (ADR) 在越南很常见,超过一半报告的ADR都涉及抗生素. 许多这些抗生素不良反应可以通过改进的处方实践来预防.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 临床药房 临床药房
背景情况:
- 抗生素在医疗保健机构中经常被处方.
- 与抗生素相关的药物不良反应 (ADR) 占报告的安全事件的很大一部分.
- 了解与抗生素相关的不良反应对于患者的安全至关重要.
研究的目的:
- 描述与越南抗生素使用相关的自发报告的副作用.
- 评估这些与抗生素相关的不良反应的可预防性.
- 确定导致可预防的副作用 (pADRs) 的关键因素.
主要方法:
- 来自越南国家药监数据库 (2018年6月至2019年5月) 的抗生素相关ADR报告的回顾性分析.
- 报告特征的描述性分析.
- 应用标准化规模来评估ADR可预防性的应用.
主要成果:
- 分析了6385份与抗生素有关的报告,占ADR报告总数的50%以上.
- 贝塔-乳酸抗生素是最经常涉及的.
- 8.4%的病例被确定为可预防的副作用,主要是由于已知过敏后不适当的处方和重新使用.
结论:
- 抗生素的使用是越南ADR的主要原因之一.
- 很大一部分与抗生素相关的副作用是可以预防的.
- 改善抗生素处方实践对于减少可预防的副作用至关重要.
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