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Updated: Jul 25, 2025

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药物-聚合物相互作用对无形固体分散物的物理稳定性的影响

Mustafa Bookwala1, Peter L D Wildfong2

  • 1School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, 422C Mellon Hall, Pittsburgh, PA, 15282, USA.

Pharmaceutical research
|June 30, 2023
PubMed
概括

无形固体分散 (ASDs) 增强药物溶解性,但可以破坏稳定. 本综述探讨了药物和聚合物之间的非共价相互作用 (NCI) 如何提高ASD的物理稳定性.

关键词:
无形固体分散的分散.药物-聚合物相互作用物理稳定性 物理稳定性热力学和动力学因素.σ-孔相互作用 σ-孔相互作用

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