运动训练在最近但不是晚期绝经后的女性中诱导了血栓生成的好处
Line Boel Nørregaard1, Kate Aiko Wickham1,2, Thomas Ehlers1
1Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
概括
绝经后不久开始运动显著降低了女性的血栓风险. 然而,在更年期后多年开始运动并没有提供相同的血栓形成风险降低益处.
科学领域:
- 心血管健康 心血管健康
- 运动生理学 运动生理学
- 绝经研究 绝经研究
背景情况:
- 定期体育活动对男性的心血管健康有好处,但对绝经后妇女的影响不太清楚.
- 运动开始的时间 (更年期后不久与更年期后的许多年) 可能会影响训练适应和健康益处.
研究的目的:
- 评估运动训练对最近 (≤5年) 和晚期 (≥10年) 绝经后女性血栓风险标志物和导管动脉功能的影响.
- 为了确定运动开始的时间在绝经后是否会影响运动诱导的适应程度.
主要方法:
- 14名近期和13名晚期绝经后妇女完成了为期8周的强化运动训练 (地板球和骑自行车).
- 干预前后评估了血栓形成风险和血管健康的标志物.
- 用线性混合模型分析数据.
主要成果:
- 运动训练显著降低了激动剂诱导的血小板反应性 (11%的降低) 和初始凝块微观结构 (约. 在最近的绝经后女性中,凝块质量减少了40%.
- 在晚期绝经后的女性中,没有观察到血栓风险标志物的这些有益变化.
- 在这两组中都没有观察到手臂或杆动脉流介导扩张的显著变化;晚期绝经后的女性显示细胞内粘附分子-1.0的增加.
结论:
- 八周的高强度运动训练有效地降低了近期更年期后妇女的血栓风险标志物,但不是那些晚期更年期后妇女.
- 在更年期后不久开始定期体育活动似乎更有效地减少血栓形成风险,而不是在许多年后开始.
- 晚期绝经后妇女缺乏益处可能与训练诱导的低度全身炎症有关.
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