Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Randomized Experiments01:13

Randomized Experiments

7.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
7.0K
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

247
Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures...
247
Ranks01:02

Ranks

265
Unlike parametric methods, nonparametric statistics are ideal for nominal and ordinal data, requiring fewer assumptions about the population's nature or distribution. This makes nonparametric methods easier to apply and interpret, as they do not depend on parameters like mean or standard deviation. One common approach in nonparametric analysis is to sort data according to a specific criterion. For instance, we might arrange weather data from hottest to coldest days in a month or rank cities...
265
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

157
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
157
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

488
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
488
Stratified Sampling Method01:16

Stratified Sampling Method

12.1K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a stratified sample, divide the population into groups called strata and then take a...
12.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating.

Genetic epidemiology·2026
Same author

Variant selection to maximize variance explained in cis-Mendelian randomization.

HGG advances·2026
Same author

Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes.

International journal of epidemiology·2026
Same author

Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.

JCI insight·2025

相关实验视频

Updated: Jul 25, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

使用双级分层方法进行非线性门德尔随机化的放松参数假设.

Haodong Tian1, Amy M Mason2, Cunhao Liu1

  • 1MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

PLoS genetics
|June 30, 2023
PubMed
概括

这项研究引入了一种用于非线性门德尔随机化的新方法,即双排列方法,改善因果推理. 它准确地估计了酒精摄入量和血压之间的关系,即使使用复杂的数据.

更多相关视频

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.2K

相关实验视频

Last Updated: Jul 25, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.2K

科学领域:

  • 流行病学 流行病学
  • 生物统计学 生物统计学
  • 遗传学 遗传学是一种遗传学.

背景情况:

  • 非线性门德尔随机化 (MR) 使用仪器变量来评估因果关系.
  • 非线性MR的标准分层方法依赖于限制性假设.
  • 违反这些假设可能会导致偏差的仪器变量估计.

研究的目的:

  • 为非线性MR开发一种新的分层方法,使参数假设放松.
  • 提高非线性MR分析中因果效应估计的准确性.
  • 解决因非线性或异质仪器暴露关系和暴露粗化带来的偏差.

主要方法:

  • 提出了"双排列方法",用于在非线性MR中创建层.
  • 该方法基于排序的暴露水平而形成层,没有严格的参数假设.
  • 通过模拟研究验证了该方法,并将其应用于酒精摄入量和缩血压数据.

主要成果:

  • 双排列方法产生了不偏见的分层特定估计和适当的覆盖率.
  • 它即使在非线性/异质仪器暴露效应和粗暴露的情况下也表现良好.
  • 模拟显示,在这些条件下,残余方法产生了实质性的偏差.

结论:

  • 双排列方法为非线性门德尔随机化提供了一个强大的方法.
  • 当标准方法由于违反假设而失败时,它提供可靠的因果估计.
  • 应用分析表明,酒精消费与缩血压之间存在积极的关联,特别是在摄入量较高的情况下.