中性蛋白与高密度脂蛋白胆固醇的比例,这是一种与急性缺血性中风相关的新型危险因素
1Department of Clinical Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Medicine
|June 30, 2023
概括
中性粒细胞与高密度脂蛋白胆固醇 (NHR) 的比率是急性缺血性中风 (AIS) 的重要预测因素. 较高的NHR水平与增加的AIS风险和严重程度相关,提供了一个新的诊断标志物.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 急性缺血性中风 (AIS) 构成了全球严重的健康负担.
- 确定用于AIS诊断和风险分层的新生物标志物至关重要.
研究的目的:
- 研究中性粒细胞与高密度脂蛋白胆固醇比率 (NHR) 和AIS之间的关系.
- 探索NHR作为潜在的诊断标记,并将其与中风严重程度相关联.
主要方法:
- 一项涉及158名AIS患者和162名健康对照者的病例控制研究.
- 多变量物流回归分析以确定AIS的独立风险因素.
- 接收器操作特征 (ROC) 曲线分析,以评估NHR的诊断价值.
- 斯皮尔曼相关性分析,以评估NHR和国家卫生研究院中风量表 (NIHSS) 分数之间的关联.
主要成果:
- 与对照组相比,AIS患者的NHR显著高于对照组 (P < .05).
- 年龄,甘油三 (TG) 和NHR被确定为AIS的独立风险因素.
- NHR显示AIS具有显著的诊断价值,曲线下的面积 (AUC) 为0.782.2.
- 在NHR和AIS严重程度之间观察到正相关性 (NIHSS得分,R = 0.558,P < .05).
结论:
- 对于AIS来说,NHR是一个重要的独立风险因素.
- NHR显示了AIS的有希望的诊断潜力,并且与中风严重程度有积极的相关性.
- NHR可以作为AIS诊断和预后的有价值的生物标志物.
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