VEGF-460 (T>C) 多态和癌症风险之间的关系:基于46份报告的系统审查和元分析
Haoran Qin1, Qiang Xiao1, Yufen Xie1
1General Surgery Department, First Affiliated Hospital of Nanchang University, Nanchang, China.
Medicine
|June 30, 2023
概括
血管内皮生长因子 (VEGF) -460多态性与整体癌症风险无关. 然而,这种单核酸多态性 (SNP) 可能会提供对肝细胞癌的保护.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 关于血管内皮生长因子 (VEGF) 基因单核酸多态 (SNP) 和癌症风险之间的关联,存在相互矛盾的证据.
- 具体而言,VEGF-460 (T/C) 多态性在各种研究中显示出不一致的结果.
- 需要进行全面的元分析来澄清VEGF-460与恶性瘤易感性之间的关系.
研究的目的:
- 进行元分析,准确评估VEGF-460多态和整体癌症风险之间的相关性.
- 调查VEGF-460多态体在对特定类型癌症,特别是肝细胞癌的易感性方面的潜在作用.
主要方法:
- 在五个主要数据库 (Web of Science,Embase,Pubmed,Wanfang和CNKI) 进行了系统的文献搜索.
- 通过手动搜索,引用跟踪和灰色文献搜索,确定了其他相关研究.
- 来自44篇符合条件的论文 (46篇报告) 的数据被聚合在一起,用于计算各种遗传模型的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 分析发现,VEGF-460多态性和主导性,衰退性,异合体,同合体和添加模型的整体恶性瘤风险之间没有显著的关联.
- 亚组分析揭示了VEGF-460多态的潜在保护作用,特别是针对肝细胞癌.
- 使用几率比率和95%置信区间来评估统计学意义,没有检测到总体关联.
结论:
- 总体而言,VEGF-460多态性与患癌症的风险增加无关.
- VEGF-460多态可能起到保护作用,可能降低肝细胞癌的风险.
- 进一步的研究可能是有必要的,以阐明在肝细胞癌中这种保护作用背后的特定机制.
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