自和膀过渡性细胞癌之间通过与自相关的 lncRNAs 进行交叉
Jie Feng1, Min Wang1, Guang-Sheng Du2
1Special Medical Department, Chongqing General Hospital, Chongqing PR China.
Medicine
|June 30, 2023
概括
这项研究确定了与9自相关的长非编码RNA (lncRNA) 签名,该签名预测了膀过渡细胞癌 (TCC) 的整体存活率. 这种签名为TCC患者提供了一个新的预后工具,突出显示了自和癌症进展之间的联系.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 自在癌症的发展和进展中起着至关重要的作用.
- 长非编码RNAs (lncRNAs) 越来越被认为是各种癌症的关键调节者,包括膀过渡细胞癌 (TCC).
- 了解TCC中自和lncRNAs之间的相互作用对于开发新的诊断和预后策略至关重要.
研究的目的:
- 通过识别与自相关的长非编码RNA (lncRNAs) 来调查自和膀过渡细胞癌 (TCC) 之间的交叉关系.
- 开发基于与自相关的 lncRNAs 的预后特征,用于预测TCC患者的整体存活率.
- 为了验证预后价值,并探索开发的签名的潜在机制.
主要方法:
- 利用了包括400名TCC患者在内的癌症基因组图谱 (TCGA) 数据集.
- 确定了与自相关的lncRNA表达特征,并使用最少绝对收缩和选择操作 (LASSO) 考克斯回归构建了预后特征.
- 进行了生存分析,接收器运行特征 (ROC) 曲线分析,名录构造和基因组丰富分析 (GSEA).
主要成果:
- 建立了与9自相关的lncRNA特征,与TCC的整体存活率有显著的关联.
- 签名显示出显著的预后价值,高风险组的5年生存率为26.0%,低风险组为56.0% (P < .05).
- 从签名中得出的风险得分是多变量分析中的独立预后因素 (P < .001),而名谱显示出良好的预测性能 (C指数 = 0.71).
结论:
- 开发的与9自相关的lncRNA特征作为膀TCC整体存活的强大和独立预测器.
- 这些发现强调了自和TCC之间的显著交叉声,由特定的lncRNAs介导.
- 这种签名有可能成为临床预后评估和指导TCC患者治疗策略的宝贵工具.
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