哺乳动物精子的双相化学运动
Meisam Zaferani1, Alireza Abbaspourrad1
1Department of Food Science, Cornell University, Ithaca 14850, New York, USA.
Physical review letters
|June 30, 2023
概括
哺乳动物的精子表现出两种不同的化学动力行为 - - 奇拉和过度活跃 - - 作为对雌性生殖道 (FRT) 内的生物化学线索的反应. 这种依赖于度的行为细化了精子搜索区域,有助于导航到受精地点.
科学领域:
- 生殖生物学 生殖生物学
- 生物物理学的生物物理.
- 细胞力学 细胞力学
背景情况:
- 精子在女性生殖道 (FRT) 的迁移对于受精至关重要.
- 了解精子如何导航生化梯度对于繁殖成功至关重要.
- 目前的知识缺乏关于精子对FRT化学线索的反应的定量数据.
研究的目的:
- 量化描述哺乳动物精子对FRT中生物化学线索的反应.
- 为了研究精子运动,质学和化学刺激剂度之间的关系.
- 在复杂的FRT环境中阐明精子导航策略.
主要方法:
- 对精子运动的实验观测,以应对不同的化学度.
- 周围介质的风湿学分析.
- 精子轨迹的最小理论建模和统计表征.
- 分析性 (循环) 和高活性 (随机重定位) 运动阶段.
主要成果:
- 哺乳动物的精子表现出两种不同的化学动力学行为:依赖媒介的质学而依赖的性和过度活跃.
- 随着化学刺激剂度的增加,有效的扩散性在两个运动阶段都会下降.
- 精子可以在性和过度活跃的阶段之间切换.
结论:
- 度依赖的化学动力学表明精子在特定FRT区域内的精细化搜索区域.
- 阶段切换表示可适应的随机导航策略 (例如,运行和,间歇性搜索).
- 这项研究为了解异质FRT中的精子导航提供了定量框架.
相关概念视频
Spermatogenesis
102.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.7K
Sperm Structure and Semen Composition
2.9K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
2.9K
Mechanism of Ciliary Motion
3.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.7K
Meiosis I
193.8K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
193.8K
Microtubules in Cell Motility
3.3K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
3.3K
Meiosis II
183.6K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
183.6K


