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狭窄性动脉的几何和血液动力学之间的关系基于计算流体动力学

Yongsheng Liu¹, Guinan Jiang¹, Xuwen Wang¹

¹Department of Interventional Neuroradiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Clinical neurology and neurosurgery

|June 30, 2023

概括

除了狭窄度之外的几何因素显著影响动脉血流. 损伤长度和血管角度影响血液动力学,这对于了解中风风险至关重要.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
心血管研究研究心血管研究

背景情况:

动脉狭窄是缺血性中风的主要危险因素.
准确评估狭窄症的严重程度对于临床决策至关重要.
血液动力学因素在动脉样斑块的进展和破裂中起着重要作用.

研究的目的:

在患有动脉狭窄症的患者中研究几何因素和血液动力学之间的关系.
确定影响狭窄性动脉血液流动特征的关键几何参数.
确定几何因子对血液动力学上显著的动脉损伤的预测值.

主要方法:

对患有大脑动脉狭窄症的患者数据的回顾性审查 (40% - 95%).
计算流体动力学 (CFD) 使用ANSYS CFX来解决纳维埃-斯托克斯方程.
相关性和后勤回归分析,以评估几何变量和血液动力学参数之间的关系.
接收器操作特征 (ROC) 分析,以评估几何因素的诊断性能.

主要成果:

穿越式压力比与狭窄度和内/外动脉角 (γ) 有显著的相关性.
横切壁剪切应力比率与狭窄度,病变长度和内部和常见动脉的光区域相关.
狭窄度和 γ 角度显示低转折压力比的高预测值 (AUC 分别为 0.87 和 0.71).
狭窄度表明高过切壁剪切应力比率 (AUC 0.77) 的良好预测值.

结论:

除了狭窄度之外的几何特征,如病变长度和血管角度,影响着动脉血液动力学.
这些几何因素对于全面了解狭窄性动脉中血液流动至关重要.
进一步的研究可能会纳入这些因素,以改善风险分层和治疗规划.

关键词:

冠状动脉冠状动脉冠状动脉计算流体动力学计算流体动力学几何几何学几何学几何学血液动力学血液动力学狭窄症 (英语:Stenosis) 是一种缩小症.

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