人体中腹前皮层病变增强了对疼痛感知期望的影响
Julian C Motzkin1, Jaryd Hiser2, Ian Carroll3
1Department of Neurology, University of California, San Francisco, CA, USA; Department of Anesthesia and Perioperative Care, University of California, San Francisco CA, USA.
概括
患有腹中前额叶皮层 (VMPFC) 病变的患者由于预期更新受损而表现出增加的疼痛不愉快感. 这表明VMPFC专门调节疼痛预期,而不是一般的疼痛影响.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 认知神经科学 认知神经科学
背景情况:
- 疼痛感知受到期望和信念的重大影响.
- 腹中前额叶皮层 (VMPFC) 参与疼痛,预测和学习.
- 以前的研究表明VMPFC在疼痛调节中的作用,但其具体功能仍在争论中.
研究的目的:
- 调查VMPFC是否对于产生对疼痛的情感反应至关重要,或者是否特别参与基于期望的疼痛调制.
- 为了区分VMPFC在一般疼痛影响与疼痛预期处理中的作用.
主要方法:
- 研究了5名双边VMPFC病变的成年人和20名健康对照者的热痛反应.
- 利用定量感官测试和带有预测线索的疼痛预期任务.
- 评估主观疼痛不愉快和自主性兴奋,以应对热刺激.
主要成果:
- 根据线索,VMPFC病变组报告了基于线索的预期疼痛的较大差异.
- 患有VMPFC病变的个人在引入意想不到的刺激时未能更新预期.
- 在VMPFC病变组中,主观疼痛的不愉快程度是通过线索更强烈地调节的.
- 两组之间没有发现整体疼痛敏感度或疼痛自主性兴奋关系的差异.
结论:
- VMPFC损伤特别增强了期望对疼痛处理的影响.
- 感官反的整合障碍,以更新预期,可能是这些影响的驱动因素.
- VMPFC在通过预期更新来调节疼痛方面发挥着特定的作用,而不是一般的情感疼痛产生.
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