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在多次IVF失败的子宫内膜异位症患者的卵细胞捐赠结果
Chloé Maignien1, Rami El Hachem1, Mathilde Bourdon2
1Université Paris Cité, Faculté de Santé, 12 Rue de l'Ecole de Médecine, 75006 Paris, France; Department of Gynaecology Obstetrics II and Reproductive Medicine, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire Cochin, 123 Boulevard de Port Royal, 75014 Paris, France.
Reproductive biomedicine online
|June 30, 2023
概括
卵子捐赠为子宫内膜异位症和多次体外受精 (IVF) 失败的妇女提供了一条可行的途径,以实现活产. 在这项研究中,无妊娠状态是活产率的唯一负面预测因素.
科学领域:
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
- 子宫内膜异位症管理管理
背景情况:
- 子宫内膜异位症显著影响女性生育能力,往往导致反复出现的体外受精 (IVF) 失败.
- 患有子宫内膜异位症相关不孕症的妇女在通过自身体外受精周期成功怀孕方面面临挑战.
研究的目的:
- 为了评估生殖结果,特别是累积活产率 (CLBR),在经过多次试管婴儿失败后接受卵细胞捐赠的子宫内膜异位症患者.
- 确定影响该患者群体活产率的预后因素.
主要方法:
- 一项观察性队列研究包括患有子宫内膜异位症相关不孕症的妇女,以及至少两次IVF/细胞内质精子注射 (ICSI) 周期失败的妇女.
- 数据是在2013年1月至2022年6月期间收集的,重点是卵细胞捐赠周期,并比较了实现活产的患者与未实现活产的患者的特征.
- 子宫内膜异位症的诊断是基于成像标准和组织学确认,分析包括单变量和多变量评估.
主要成果:
- 57名患者在244次失败的自身体外受精周期后接受了90个卵细胞捐赠周期.
- 每名患者的总累积活产率 (CLBR) 为63.2% (36/57).
- 无妊娠状况被确定为活产率 (P=0.002) 的唯一独立负面预测因素;之前的子宫内膜异位症手术没有显著影响结果.
结论:
- 卵子捐赠是改善子宫内膜异位症妇女活产率的有希望的策略,这些妇女经历了反复的试管婴儿失败.
- 这项研究强调了卵细胞捐赠作为这一具有挑战性的不孕症群体的治疗选择的有效性.
- 在咨询接受卵细胞捐赠的子宫内膜异位症患者时,应考虑无妊娠状态.
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