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在急诊室实施快速流感PCR后,处方抗菌剂

Alec Wesolowski¹, Jessica L Miller¹, Maureen Shields²

¹Department of Pharmacy Services, Advocate Lutheran General Hospital, 1775 Dempster St, Park Ridge, IL 60068, United States of America.

The American journal of emergency medicine

|June 30, 2023

概括

在急诊室 (ED) 进行的快速流感聚合酶链反应 (PCR) 测试显著减少了不必要的抗生素处方,并优化了抗病毒使用. 这种诊断改进有助于抗菌药物管理和对流感病例的患者护理.

科学领域:

传染性疾病传染性疾病
临床诊断临床诊断临床诊断
抗微生物药物管理委员会

背景情况:

流感和细菌性肺炎有共同的症状,导致在诊断不确定时,在急诊室 (ED) 可能过度使用抗生素.
快速流感诊断测试比传统方法提供更快的结果,可能改善抗菌药物管理.
这项研究评估了快速流感PCR测试对ED抗生素和抗病毒处方模式的影响.

研究的目的:

在实施快速流感PCR测试之前和之后,在ED中比较抗生素和抗病毒处方.
评估快速流感PCR对ED内关键临床和操作指标的影响.

主要方法:

一个单一中心的回顾性队列研究,比较了患有流感的儿童和成年患者,他们的流感测试呈阳性.
收集关于抗生素/抗病毒处方,治疗持续时间,测试周转时间,ED停留时间和再入院的数据.
多变量逻辑回归分析了与抗微生物药物处方相关的患者因素.

主要成果:

快速的流感PCR测试与抗生素处方显著减少 (39.4%对比8.9%) 和抗病毒处方增加 (24.2%对比61.1%) 相关.
快速测试显著减少了ED停留时间 (4.9小时 vs 3.4小时) 和测试周转时间 (27小时 vs 3.5小时).
喘,免疫抑制和5岁以下的年龄被确定为抗病毒处方的预测因素.

结论:

在ED中实施快速流感PCR测试有效地减少了抗生素的使用.
快速测试优化了抗病毒疗法,特别是在高风险流感患者中.
通过快速PCR进行更快的诊断,改善了ED中的抗菌药物管理和患者管理.

关键词:

抗微生物药物管理管理诊断诊断诊断诊断流感是一次流感.奥塞尔塔米维尔 (oseltamivir) 是一种

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