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Updated: Jul 26, 2026

Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
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发素A-E,来自海洋海绵Phakellia sp.的环. 在LC-MS的指导下

Can Kong1, Ying Wu2, Hui-Min Zhao2

  • 1Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensor of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, Shandong, People's Republic of China.

Bioorganic chemistry
|June 30, 2023
PubMed
概括

海洋海绵产生了五种新的环素,法凯利辛A-E.法凯利辛A对WSU-DLCL-2细胞表现出显著的细胞毒性活性,诱导细胞循环停止和细胞亡.

关键词:
循环类酸是一种循环类酸.细胞毒性活动的细胞毒性.帕凯利亚 sp. 在这里.结构阐明 结构阐明

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Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...