复发性缓解性多发性硬化症的认知轨迹:多重进化趋势的证据
Frédéric London1, Alice De Haan2, Zohra Benyahia2
1Department of Neurology, CHU UCL Namur Site Godinne, Université Catholique de Louvain (UCLouvain), 1 Avenue G. Thérasse, Yvoir B-5530, Belgium.
Multiple sclerosis and related disorders
|June 30, 2023
概括
多发性硬化症 (MS) 的认知障碍可能会随着时间的推移而改善,而不是遵循下降的路径. 在这项研究中,患者报告的结果没有预测未来的认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 医学研究 医学研究
背景情况:
- 认知障碍 (CI) 在多发性硬化症 (MS) 中很常见,但其进展是可变的.
- 在MS中预测CI是具有挑战性的,因为基线决定因素的纵向数据有限.
- 患者报告结果指标 (PROMs) 对MS未来CI的预测价值尚未被探索.
研究的目的:
- 为了研究复发性复发性多发性硬化症 (RRMS) 患者的认知状态变化,开始新的疾病修饰治疗 (DMT).
- 在12个月内评估PROMs对RRMS患者未来CI的预测价值.
主要方法:
- 59名RRMS患者的未来12个月随访.
- 包括临床 (EDSS),神经心理 (BVMT-R,SDMT,CVLT-II),MRI和PROM在内的综合评估.
- 纵向逻辑回归分析以确定12个月后CI的基线预测因素.
主要成果:
- 56%的患者在基线时有CI,在12个月后降至38%.
- 在12个月后,认知测试得分和大多数PROM得分都出现了显著的改善.
- 在基线时,较低的教育程度和较高的身体残疾预测SDMT和BVMT-R的表现较差,但PROM和MRI指标没有预测CI.
结论:
- 在MS的认知障碍似乎是动态的,不一定是渐进性的下降.
- 目前,PROMs对于预测RRMS患者未来认知障碍并不有用.
- 需要进一步的长期随访来证实这些发现.
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