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Updated: Jul 25, 2025

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

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亨廷丁蛋白的功能子域的划分及其与HAP40的相互作用

Matthew G Alteen1, Justin C Deme2, Claudia P Alvarez3

  • 1Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; POINT Biopharma, 22 St Clair Avenue E Suite 1201, Toronto, ON M4T 2S3, Canada.

Structure (London, England : 1993)
|June 30, 2023
PubMed
概括

研究人员开发了新的狩猎 (HTT) 蛋白子域,以研究其复杂的相互作用. 这些工具有助于对HTT的研究.

关键词:
亨廷顿病就是亨廷顿病.冷电子显微镜的使用方法神经退行症的神经退行症蛋白质净化 蛋白质净化蛋白质结构 蛋白质结构蛋白质与蛋白质的相互作用

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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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