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Updated: Jul 25, 2025

Measuring Phagosome pH by Ratiometric Fluorescence Microscopy
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溶解体LAMP蛋白通过直接抑制TMEM175通道来调节溶解体pH值

Jiyuan Zhang1, Weizhong Zeng2, Yan Han1

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Molecular cell
|June 30, 2023
PubMed
概括

lysosome相关的膜蛋白 (LAMP-1和LAMP-2) 通过抑制TMEM175通道来调节细胞酸度. 这种相互作用对于维持 lysosomal 功能和预防疾病至关重要.

关键词:
在LAMP-1和LAMP-2系统中.在TMEM175中,我们得到了TMEM175.溶酶体中的LAMP蛋白质.溶酶体的水解功能溶酶体pH的恒常性.溶酶体酸化发生的原因这是帕金森病的危险因素.

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