孕产妇补铁和与铁代谢相关的基因多态性对出生结果的相互作用:一项以中国语进行的前性研究
Danmeng Liu1, Yue Cheng2, Pengfei Qu1
1Translational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, China.
The Journal of nutrition
|June 30, 2023
概括
母亲遗传因素会影响怀孕期间补充铁的有效性. 补充铁对胎儿的生长有好处,更多的是母亲具有较高的低铁状况遗传风险.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 人类遗传学 人类遗传学
背景情况:
- 怀孕期间补充铁是常见的,但其有效性可能受到母亲遗传学的影响.
- 以前的研究表明,需要研究母亲遗传背景和铁补充剂对出生结果的相互作用.
研究的目的:
- 检查母亲补充铁和铁代谢遗传变异与怀孕结果之间的相互作用.
- 评估与铁状况相关的遗传多态如何改变补充铁的效果.
主要方法:
- 来自中国西北部随机对照试验的860名女性的副研究,将叶酸 (FA) 与FA + 铁补充剂进行比较.
- 在铁代谢基因中的六个单核酸多态 (SNPs) 的基因定型和遗传风险得分 (GRS) 的计算.
- 使用概括估计方程进行统计分析,以评估铁补充剂,SNP和GRS之间对出生结果的相互作用.
主要成果:
- 铁补充剂和特定SNP (rs7385804,rs149411,rs4820268) 和GRS (未加权和加权) 之间在出生体重上观察到显著的相互作用.
- 在具有较高的低铁/血红蛋白状况遗传风险 (更多效应等位基因) 的妇女中,FA + 铁补充剂显著增加了出生体重.
- 相反,补充铁的情况显示,在基因风险较低的妇女中,出生体重下降的趋势和低出生体重的风险增加.
结论:
- 母亲的遗传背景显著调节了怀孕期间补充铁的有效性.
- 向的铁补充剂可能在具有较高遗传倾向的母亲对低铁状况的胎儿生长更有益.
- 对产前补充铁的个性化方法,考虑到遗传因素,可以优化分娩结果.
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