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节拍器插入部位有助于心肌功能异常和组织病理学异常
Daniel A Castellanos1, Chrystalle Katte Carreon2, Ashwin Prakash1
1Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
室腔节拍线可以损害心脏功能. 这项研究发现,插入部位往往表现出异常的心脏壁运动,与减少喷射率和心肌纤维化等心肌变化有关.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 病理学 病理学 病理学
背景情况:
- 已知心室节奏会导致心肌功能障碍.
- 腹腔固定对心肌功能的影响仍未得到充分研究.
研究的目的:
- 在患有心室导向的患者中评估区域和全球心室功能.
- 使用心脏计算机断层扫描 (CCT) 和组织学,将特征与观察到的功能模式相关联.
主要方法:
- 一个回顾性单中心研究,涉及患有心室导管的患者.
- 对区域壁运动异常的cine CCT的分析和心脏样本的组织学检查.
主要成果:
- 在42%的插入部位中发现了区域壁壁运动异常,在活跃节奏中更为普遍 (55%vs18%).
- 患有这些异常的患者表现出较低的全身心室喷射分数 (38%与53%对比).
- 组织学揭示了心肌压缩,纤维化和化在活性下.
结论:
- 插入部位的异常很常见,并与全身心室功能障碍有关.
- 活下的组织病理变化可能是这些功能缺陷的基础.
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