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相关概念视频

Amyloid Fibrils03:03

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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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What is Monogastric Digestion?01:50

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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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相关实验视频

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Performing and Processing FNA of Anterior Fat Pad for Amyloid
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胃肠 Amyloidosis:一个经常意想不到的发现,具有全身影响.

Catherine E Hagen1, Surendra Dasari2, Jason D Theis1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

Human pathology
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概括

胃肠粉症有12种类型,其中AL,ATTR和AA是最常见的. 大多数病例是意想不到的,但表明系统性疾病,需要活检进行准确的诊断和治疗.

关键词:
氨基粉症是什么 氨基粉症是什么心脏的参与心脏的参与.胃肠道 胃肠道 胃肠道蛋白质组学是指蛋白质组学.系统性氨基粉症的发生.

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科学领域:

  • 胃肠病学 胃肠病学
  • 病理学 病理学 病理学
  • 遗传学 遗传学 是一个

背景情况:

  • 胃肠道 (GI) 粉症是常见的,但在发病率,特征和系统性影响方面不太了解.
  • 十二种不同的类型的粉样化病可以影响肠道.

研究的目的:

  • 分析各种肠道粉样化症类型的发病率,临床病理特征和系统影响.
  • 评估蛋白质组学在GI标本中粉样类型的有用性.

主要方法:

  • 使用蛋白质组学类型的2511个GI粉样物的回顾性分析 (2008-2021年).
  • 对一组病例中的临床和形态特征的审查.
  • 粉样蛋白类型的识别,包括AL,ATTR,AA等.

主要成果:

  • 粉样性粉症占77.9%,ATTR占11.3%,AA占6.6%的病例.
  • 在ATTR病例中,突变发生在24.4%的患者中.
  • 常见的活检指示包括腹,出血,疼痛或体重减轻;心脏参与在AL (83.5%) 和ATTR (100%) 患者中很常见.

结论:

  • 肠道粉样性多样,其中AL,ATTR和AA是主要的类型.
  • 大多数肠道粉样化是意想不到的,但意味着系统性疾病,需要活检.
  • 蛋白质组学对于准确的打字至关重要,指导适当的治疗.