在COVID-19之前和之后,Graves甲状腺功能障碍的发生率,信使RNA疫苗接种
Mayumi Endo1, Jessica Pinto2, Mara Y Roth1
1Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington.
概括
这项研究发现,在接种COVID-19疫苗后,Graves的甲状腺功能障碍 (GD) 发生率没有增加. 虽然观察到一些疫苗接种后格雷夫斯甲状腺功能障碍 (PVGD) 的病例,但整体病例率在统计学上保持不变.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 新出现的病例报告表明,COVID-19疫苗接种和早期发病的Graves甲状腺功能障碍 (PVGD) 之间存在联系.
- 了解COVID-19疫苗接种对格雷夫斯甲状腺功能障碍 (GD) 发生率的潜在影响对于公共卫生至关重要.
- 之前的研究没有明确确确立因果关系.
研究的目的:
- 调查COVID-19疫苗接种引入后,格雷夫斯甲状腺功能障碍 (GD) 的发生率是否显著增加.
- 为了比较COVID-19疫苗广泛实施之前和之后的新发性GD的比率.
- 为了识别和描述疫苗接种后格雷夫斯甲状腺功能障碍 (PVGD) 的病例.
主要方法:
- 采用了比较性研究设计,分析了单个学术中心的新发性GD病例.
- 收集了两个不同的时间段的数据:疫苗接种前期 (2017年12月至2019年10月) 和疫苗接种后期 (2020年12月至2022年10月).
- 接种疫苗后的Graves甲状腺功能障碍症 (PVGD) 是通过特定的实验室确认和与疫苗接种相关的症状发病时间表来定义的.
主要成果:
- 在疫苗接种前和疫苗接种后期间 (P = .52) 之间,在格雷夫斯甲状腺功能障碍 (GD) 的总体发病率中没有观察到统计学上显著的差异.
- 新发性GD的发病率仍然相似,疫苗接种前有131例,疫苗接种后有138例.
- 在接种后组的138名新诊断的患者中,有24名 (17.4%) 符合PVGD的标准,但关键的人口和免疫因素与对照组没有差异.
结论:
- 引入COVID-19疫苗接种并没有与新发格雷夫斯甲状腺功能障碍 (GD) 发病率的增加有关.
- 虽然一小部分患者在接种疫苗后患有格雷夫斯甲状腺功能障碍 (PVGD),但这并没有转化为整体GD病例的统计学上显著增加.
- 在PVGD患者中,自由T4水平的中位数略高,但这一发现缺乏统计学意义.
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