老年人中的Levothyroxine剂量:来自巴尔的摩长度老龄化研究的建议
Colleen Gavigan1, Enoch J Abbey2, John McGready3
1Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Endocrinology, Diabetes and Metabolic Diseases, Medical University of South Carolina, Charleston, South Carolina.
概括
对于老年人来说,甲状腺激素替代剂量低于年轻人群. 在老年人中,基于体重的新估计,对于Levothyroxine治疗的估计比目前的推低三分之一.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺激素代谢和剂量要求随着年龄的增长而变化.
- 目前的指导方针建议对患有甲状腺功能低下症的老年人进行剂量定位.
- 需要针对老年人服用勒沃西的具体基于体重的推.
研究的目的:
- 为了确定老年人适合的levothyroxine剂量.
- 为65岁及以上的个人制定基于体重的Levothyroxine推.
- 为了确定老年甲状腺功能低下患者过度治疗的风险因素.
主要方法:
- 来自巴尔的摩长度老龄化研究的65岁以上的参与者中,对levothyroxine剂量的分析.
- 使用实际体重 (ABW) 和理想体重 (IBW) 计算平均levothyroxine剂量的计算.
- 回归分析以确定过度治疗的风险因素,考虑多次访问.
主要成果:
- 甲状腺上升腺素的平均剂量为1.09μg/kg ABW或1.35μg/kg IBW.
- 84%的无甲状腺老年人接受了<1.6μg/kg.
- 肥胖个体需要基于ABW而不是IBW的较低剂量.
结论:
- 对于老年人来说,每人体重的levothyroxine剂量比年轻人群体低约三分之一.
- 已确定的老年人的估计是1.09μg/kg ABW和1.35μg/kg IBW.
- 这些发现支持针对老年人甲状腺功能低下症治疗的经过修订的基于体重的剂量建议.
相关概念视频
01:01Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
01:21Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
4.2K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.2K
01:20Synthesis and Regulation of Thyroid Hormones
4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K
01:11Renal Failure: Dose Adjustments
123
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
123
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K