微塑料在系统毒性的新兴作用:反应性氧物种 (ROS) 的参与
1Department of Biochemistry, School of Biosciences, The Assam Royal Global University, NH-37, opp. Tirupati Balaji Temple, Betkuchi, Guwahati, Assam 781035, India.
The Science of the total environment
|June 30, 2023
概括
微塑料 (MP) 和纳米塑料 (NP) 的塑料污染对生态系统和人类健康构成重大威胁. 这些粒子诱导氧化应激和细胞损伤,导致各种器官毒性,需要进一步的研究和缓解策略.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 塑料污染,特别是微塑料 (MP) 和纳米塑料 (NP),是全球环境的一个主要问题.
- MP和NP从巨型塑料中降解,对陆地,海洋生态系统和人类健康构成风险.
- 有证据表明,MPs/NPs在生物水平上的毒性涉及到活性氧物种 (ROS).
研究的目的:
- 审查微塑料和纳米塑料对生物系统的有害影响.
- 突出反应性氧物种 (ROS) 在MP/NP毒性的作用.
- 发现塑料污染研究和减缓策略中的差距.
主要方法:
- 关于微塑料和纳米塑料毒性研究的文献综述.
- 对MP/NP诱导的损伤细胞和分子机制的分析.
- 检查受MP/NP暴露影响的信号通路.
主要成果:
- MPs/NP 积聚在线粒体中,扰乱细胞呼吸并增加ROS的产生.
- 产生ROS导致DNA损伤,蛋白质氧化,脂质过氧化和抗氧化防御的损害.
- 接触MP/NP会触发各种信号通路 (例如p53,MAPK,Nrf2,PI3K/Akt,TGF-β) 并导致器官损伤 (肺,心脏,神经,脏,免疫,生殖,肝脏).
结论:
- 微塑料和纳米塑料主要通过氧化应激诱导显著的细胞损伤和器官毒性.
- 需要进一步的研究,重点是先进的模型系统,多学科的方法,跨学科的合作,和有效的缓解策略.
- 解决塑料污染问题需要采取全面的方法来保护环境和人类健康.
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