皮素和来自Catalpa ovata的衍生物具有抗氧化作用,具有抗氧化作用
Liuqiang Zhang1, Longlong Wu1, Jingwen Liu2
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Fitoterapia
|June 30, 2023
概括
从Catalpa ovata G. Don中发现了六种新的虹膜衍生物. 通过激活Nrf2通路,一些化合物表现出显著的抗氧化活性.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 卡塔尔帕·奥瓦塔 (Catalpa ovata G. Don) 是一种传统的药用植物.
- 化物衍生物已知具有各种生物活性.
研究的目的:
- 从Catalpa ovata G. Don.中分离和描述新的虹膜衍生物.
- 通过Nrf2通路激活来评估分离化合物的抗氧化潜力.
主要方法:
- 使用光谱数据 (NMR,MS) 进行隔离和结构阐明.
- 通过电子圆二元论 (ECD) 计算来确定绝对配置.
- 在293个T细胞中使用Nrf2转录通路激活的体外抗氧化活性测定.
主要成果:
- 分离了6种新的虹膜衍生物 (1-6) 和12种已知的化合物 (7-18).
- 化合物1,3,4,6-8,10-12,14,15,17和18在25μM时表现出显著的Nrf2激动作用.
- 为化合物1-13提出了一个假设的生物合成途径.
结论:
- 卡塔尔帕·奥瓦塔 (Catalpa ovata G. Don) 是一种富含具有抗氧化功能的虹膜衍生物的丰富来源.
- 几种孤立的虹膜体,特别是1,3,4,6-8,10-12,14,15,17和18的化合物,显示出作为Nrf2激活剂的希望.
- 对这些化合物的生物合成途径和治疗潜力的进一步研究是有必要的.
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