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Updated: Jul 24, 2025

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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通过分子间力生物传感器揭示的核膜菌株状态

Brooke E Danielsson1, Bobin George Abraham2, Elina Mäntylä2

  • 1Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.

Nature communications
|June 30, 2023
PubMed
概括

研究人员开发了一种新型生物传感器,用于测量核层 (核中的蛋白质丝) 上的机械力. 这种工具揭示了对核膜起作用的显著力量,影响DNA和核结构.

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相关概念视频

Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
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